As long-time observers, promoters and participants in the evolutionary processes of the healthcare system, we invite you to a joint summary of two decades of discussions, but also actions and experiences. The opening session was devoted to redefining the approach to data, scientific evidence and health technology assessment (HTA). The meeting will be the basis for a new look at data-driven, evidence-driven healthcare systems. We will also introduce the concept of NextGen Evidence and show examples of its application in practice.
With the development of digitalization, two key opportunities have emerged:

1. 1. integration of mass data from various sources (RWD, registers, new digital technologies)
   2. modern tools for analyzing this data (AI, predictive modeling).

By directing attention and effort to these new fields, we have a chance to evolve the assessment of health technologies. Perhaps we will obtain tools that take into account the real conditions of a holistic healthcare environment and perform assessment with minimal delay in relation to real time (real time approach).
This approach shifts the focus from clinical trials to more flexible evidence models - with the potential to optimize the organization of care based on full data sets. Barriers to implementation (including costs) and behavioral aspects for medicines, medical devices or system solutions at the level of service providers, but also nationally and even internationally will also be discussed. top